With Marine Corps experience and an impressive dossier of solved cases, Special Agent Olivia Dunham was a rising star in the FBI. But now, horrified by the tragedy of Flight 627 and stunned by the betrayal of someone she trusted, Olivia can no longer return to the world of traditional criminal investigations. As she delves ever deeper into the dangerous world of fringe science, Olivia comes to realize that science and technology have already advanced beyond our dreams... and nightmares.

Chosen by Homeland Security Agent Phillip Broyles, Olivia has assembled a task force to investigate The Pattern - a mysterious sequence of unexplained phenomena suggestive of someone or something performing experiments on the world. With the help of mad genius Walter Bishop and his estranged son Peter, she aims to bring high-tech criminals to justice, while defusing previously unimaginable threats to national security.